Description
PT-141 Peptide (Bremelanotide) Product Description
PT-141 peptide, also known as Bremelanotide, is a synthetic cyclic heptapeptide developed from the melanocortin peptide family. It is a selective melanocortin receptor agonist that primarily targets the MC3R and MC4R receptors within the central nervous system. Unlike phosphodiesterase type-5 (PDE5) inhibitors that act on blood vessels, PT-141 works by influencing neural pathways associated with sexual arousal and desire.
Its unique mechanism has made PT-141 a widely studied research peptide in investigations involving sexual behavior, reproductive physiology, neuroendocrine signaling, and melanocortin receptor biology. Current research also explores its potential role in central nervous system function, dopamine signaling, and neurobehavioral regulation.
Research Use Only. Not intended for human consumption or therapeutic use.
How PT-141 Works
PT-141 functions by activating melanocortin receptors, particularly MC3R and MC4R, located in regions of the brain involved in sexual motivation and behavioral responses.
Activation of these receptors stimulates neurons within the hypothalamus and associated limbic structures that regulate sexual desire, arousal, motivation, and reward processing. Unlike compounds that rely primarily on nitric oxide-mediated vasodilation, PT-141 acts centrally through neurochemical signaling pathways.
Research suggests PT-141 may influence:
- Melanocortin receptor signaling
- Dopaminergic neurotransmission
- Hypothalamic activation
- Sexual motivation pathways
- Neuroendocrine regulation
- Appetite and energy balance
PT-141 Peptide Benefits
Current laboratory research suggests PT-141 may support investigations involving:
- Sexual arousal mechanisms
- Male reproductive physiology
- Female sexual behavior
- Libido regulation
- Central nervous system signaling
- Melanocortin receptor biology
- Dopamine pathway research
- Neuroendocrine function
- Erectile function models
- Sexual motivation studies
- Hypothalamic activation
- Appetite and energy homeostasis
PT-141 Peptide Dosage
- Recommended Dose: 1.75 mg administered via subcutaneous injection.
- Timing: Inject at least 45 minutes before anticipated sexual activity.
- Maximum Frequency: Do not administer more than one dose within a 24-hour period.
- Monthly Limit: Do not exceed 8 doses per month.
- Administration Sites: Common injection sites include the abdomen or thigh, rotating injection sites when possible.
This dosing regimen is based on the approved use of bremelanotide for hypoactive sexual desire disorder (HSDD). Research involving PT-141 in other settings may use different protocols depending on the study design.
PT-141 Peptide Effects of PT-141
Experimental studies have associated PT-141 with several biological effects.
Central Nervous System Activation
PT-141 primarily acts within the brain by activating melanocortin receptors involved in behavioral and motivational responses. Research suggests this central mechanism differentiates it from compounds that act primarily through vascular pathways.
Sexual Desire and Arousal Research
One of the most extensively studied applications of PT-141 involves sexual function. Experimental and clinical research has investigated its effects on:
- Sexual desire
- Libido
- Arousal
- Sexual motivation
- Erectile response
- Female sexual behavior
Unlike PDE5 inhibitors, PT-141 may influence desire before physical response by acting directly on neural circuits associated with sexual behavior.
Neuroendocrine Regulation
PT-141 has been examined for its ability to activate hypothalamic neurons involved in reproductive signaling. Researchers continue investigating how melanocortin receptor activation may regulate hormonal and behavioral pathways associated with reproduction.
Dopamine and Reward Signaling
Research suggests PT-141 may enhance dopaminergic activity within specific brain regions linked to motivation and reward processing. These effects continue to be explored in studies involving behavioral neuroscience.
Appetite and Energy Balance
Because MC3R and MC4R also participate in metabolic regulation, PT-141 has attracted research interest regarding:
- Appetite control
- Feeding behavior
- Energy expenditure
- Glucose metabolism
- Metabolic signaling
Research Applications
PT-141 continues to be investigated across numerous scientific disciplines, including:
- Sexual dysfunction research
- Male reproductive health
- Female sexual health
- Melanocortin receptor biology
- Behavioral neuroscience
- Dopamine signaling
- Neuroendocrinology
- Hypothalamic function
- Erectile physiology
- Appetite regulation
- Energy metabolism
PT-141 Peptide Specifications
Peptide Name: PT-141
Alternative Names: Bremelanotide
Peptide Sequence:
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular Formula:
C₅₀H₆₈N₁₄O₁₀
Molecular Weight:
1025.2 g/mol
CAS Number:
189691-06-3
Storage
- Store the lyophilized peptide refrigerated or frozen.
- Protect from heat, moisture, and direct sunlight.
- After reconstitution, refrigerate at 2–8°C (35.6–46.4°F).
- Avoid repeated freeze-thaw cycles to preserve peptide stability.
